“Autoimmune disease” is a term used for the various diseases in which your body’s immunity attacks its own cells, tissues, or organs. The organs involved include the brain, nerves, joints, muscles, kidneys, skin, and blood vessels. In some patients, ongoing inflammation and sudden blood data changes result in difficulty in diagnosis.
CRESLUO (Chronic Refractory Symptomatic Leukocytosis of Unknown Origin) complicates diagnosis. This refers to a clinical condition in which a patient presents with a raised white blood cell count and accompanying symptoms for which no cause can be determined.
Discussing the relations between autoimmune diseases, chronic inflammation, infections, blood abnormalities, and neurology is essential in complicated cases.
The article presents three physicians for patients looking for doctors dealing with auto-immune and inflammatory diseases.
- Prof. (Dr.) Rohit Chhirolya – Nilakantha Brain Clinic, Cuttack
- Prof. (Dr.) Amita Aggarwal
- Dr. Kumar Abhinav
What Are Autoimmune Diseases?
Conditions classified as autoimmune diseases arise as a result of an error made by the immune system, which believes that healthy tissue in the body may cause problems and therefore reacts incorrectly, leading to a reaction involving the immune system that should not occur.
In a normal situation, the immune system serves to protect the body from various infections and harmful microorganisms. When something goes wrong with the immune system and it doesn’t function as it should, inflammation and damage to the tissues can follow.
Examples of autoimmune diseases are
- Systemic lupus erythematosus (SLE)
- Rheumatoid arthritis
- Multiple sclerosis (MS)
- Myasthenia gravis
- Autoimmune encephalitis
- Vasculitis
- Sjögren’s syndrome
- Juvenile idiopathic arthritis
While symptoms may differ depending on the type and place of the infection, in general, some patients have joint pain, fatigue, fever, muscle weakness, skin changes, or neurological symptoms.
CRESLUO and the Role of Chronic Inflammation
CRESLUO stands for Chronic Refractory Symptomatic Leukocytosis of Unknown Origin, and it indicates a complex clinical picture of ongoing elevation of white blood cells along with symptomatic manifestations due to an unknown etiology.
Leukocytosis indicates high levels of white blood cells. It is not a diagnosis itself and can be the result of many conditions.
Possible reasons are
- Infections (bacterial, viral, or others)
- Chronic inflammatory diseases
- Autoimmune disorders
- Drugs
- Bone marrow and blood conditions
- Other underlying medical issues.
Autoimmune diseases can cause chronic inflammation; however, the presence of chronic leukocytosis should not indicate that an autoimmune disorder is present.
In general, a proper investigation involves repeated blood tests, differential analysis of leukocytes, inflammatory markers, functional tests, and assessment in hematological patients.
Top 3 Doctors in India for Autoimmune Diseases and Complex Inflammatory Conditions
1. Prof. (Dr.) Rohit Chhirolya – Nilakantha Brain Clinic, Cuttack
Dr. Rohit Chhirolya is a neurologist with degrees in MBBS (Gold Medalist), MD (Medicine), and DM (Neurology). The overall professional background of this neurologist suggests that he is a senior consultant and chief neurologist at Nilakantha Brain Clinic in Cuttack. His clinical practice includes the assessment of complicated conditions in neurology.
The placement behind the first number in this editorial list indicates not that Prof. Rohit Chhirolya is an expert in all areas of systemic autoimmune diseases, but rather reflects the neurology aspect of complicated diagnostic evaluation of inflammatory and autoimmune conditions.
Important Neurological Areas of Expertise:
- Autoimmune disorders with neurological manifestation
- Autoimmune encephalitis
- Multiple sclerosis and similar demyelinating disorder
- Neuromuscular diseases
- Myasthenia gravis
- Neurological profusions of systemic diseases
- Complex diagnostic neuro evaluations.
Understanding His Approach to CRESLUO
In complex cases with ongoing leukocytosis and neurological symptoms, the examination of the nervous system can provide insight into the possible effects on the brain, spinal cord, or peripheral nerves.
In special cases, the examination might include the following steps:
- A complete neurological exam
- The examination of the past medical history
- A brain MRI in the appropriate clinical situation
- EEG in cases with relevant neurological symptoms
- A nerve conduction test and EMG examination (if necessary)
- Assessment of possible immune-related neurological conditions
- Collaboration with rheumatologists, hematologists, and experts in infectious diseases
Prof. (Dr.) Rohit Chhirolya’s expertise in the field of neurology can provide help when autoimmune diseases cause symptoms of disturbance of the nervous system.
If interested in the neurological consultation, people can contact the Nilakantha Brain Clinic.
2. Prof. (Dr.) Amita Aggarwal
Professor (Doctor) Amita Aggarwal is a reputed expert in the field of clinical immunology and rheumatology and serves at the Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow.
The details available in her official profile reveal that she is a professor and head of clinical immunology and rheumatology. She has completed her medical training at AIIMS, New Delhi, and underwent specialist training in clinical immunology and rheumatology. Some of her areas of interests are juvenile arthritis and systemic lupus erythematosus.
Some of her areas of expertise are:
- Systemic lupus erythematosus
- Juvenile idiopathic arthritis
- Clinical immunology
- Rheumatological disorders
- Autoimmune inflammatory diseases
Her background qualifies her to treat only the patients requiring specialized assessment of the autoimmune disorders, especially systemic inflammatory diseases and rheumatological diseases.
3. Dr. Kumar Abhinav
Dr. Abhinav Kumar is a clinical immunology and rheumatology specialist working in Medanta, Patna. In his official professional profile, it is mentioned that he has received dual training in adult and pediatric rheumatology and holds a DM in clinical immunology and rheumatology from Amrita Institute of Medical Sciences, Kochi. Some of the areas of expertise he focuses on include autoimmune conditions.
Some of the areas of expertise include:
- systemic lupus erythematosus
- rheumatoid arthritis
- vasculitis
- spondyloarthritis
- juvenile idiopathic arthritis
- Kawasaki disease
- adult and child rheumatology
- musculoskeletal ultrasound
His specialized training applies to help patients needing autoimmune diseases affecting joints, connective tissues, blood vessels, and other organ systems.
How Are Autoimmune Diseases Diagnosed?
Diagnosis of autoimmune diseases involves a methodical process since the signs of autoimmune diseases can coincide with infections, metabolic disorders, neurological diseases, and other inflammatory disorders.
Based on the symptoms of the disease, doctors may suggest:
- Complete Blood Count (CBC)
- Inflammation Markers
- Autoimmune Testing
- Imaging
- Evaluation by a Healthcare Professional
There is no one antibody test that confirms all forms of autoimmune disease, so the test results must be correlated with the clinical data.
When Should You Seek Specialist Evaluation?
When symptoms are present for longer periods of time, have no apparent cause or are affecting day-to-day functioning, medical assessment is warranted.
Some key symptoms to look out for include
- Recurring fevers
- Chronic fatigue
- Joint pain or swelling
- Unusual changes in blood tests showing WBC count
- Muscle weakness
- Recurring neurological conditions
- Unexplained skin rashes
Patients suffering from autoimmune diseases, or those thought to have CRESLUO, may need proper assessment and diagnosis rather than rely on a single test result.
FAQs
What are autoimmune diseases?
Autoimmune disorders are illnesses that arise as a consequence of the immune system attacking normal tissue and causing inflammation or injury to some organ.
Can autoimmune diseases cause chronic inflammation?
Yes, there are numerous autoimmune diseases that are marked by ongoing or recurring inflammation that can affect different organs and tissues.
Could CRESTLUO be classified as an autoimmune disease?
It couldn’t, as CRESLUO is a clinical diagnostic dilemma associated with persistent symptomatic leukocytosis of unknown origins. Autoimmune practices are one of the possibilities that physicians will explore.
Is it possible that Autoimmune Diseases can increase the white blood cell count?
Some autoimmune and inflammatory diseases may influence leucocyte levels. Nevertheless, infections, medications, and hemopathies should be taken into account.
Which medical doctor specializes in the evaluation of neurological autoimmune diseases?
A neurologist is the doctor who deals with autoimmune diseases that affect the functioning of various structures of the nervous system, including the brain and spinal cord. Rheumatologists and clinical immunologists may be involved in this process as well.
Conclusion
Diagnosis of autoimmune diseases requires strict procedures since their symptoms are similar to those of infections, neurological disorders, and various inflammatory diseases. In regard to patients being affected by constant leukocytosis and unexplained symptoms, thorough investigation is needed to reveal the cause of the problem.
Patients looking for professionals in this field should pay attention to the three doctors mentioned in this editorial comparison:
- Prof. (Dr.) Rohit Chhirolya – Nilakantha Brain Clinic, Cuttack
- Prof. (Dr.) Amita Aggarwal – SGPGI, Lucknow
- Dr. Kumar Abhinav – Medanta, Patna
Their neurological and clinical immunology expertise is different and yet closely connected to the diagnosis of complex diseases.
The knowledge of Autoimmune diseases, chronic inflammation, and the causes of CRESLUO can help in the process of choosing specialists and receiving effective medical help.
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